Effect of Ivermectin on the Expression of P-Glycoprotein in Third-Stage Larvae of Haemonchus contortus Isolated from China

Haemonchus contortus poses a severe hazard to the healthy development of sheep industry and threatens welfare sheep. Ivermectin is primary anthelmintic used for prevention treatment H. parasitism. However, widespread uncontrolled application ivermectin has resulted in spread resistant strains contortus. P-glycoprotein (P-gp) plays important roles pharmacology toxicology ivermectin, changes P-gp expression levels can be analyze resistance ivermectin. This study aimed effects on L3 larvae isolated from China evaluate whether strains. In absence drug treatment, ivermectin-resistant showed increased P-gp11 (p < 0.01) compared with sensitive elsewhere, whereas expressions P-gp2 P-gp9.1 were downregulated 0.01). When same strain was before after obvious differences observed between different Ivermectin-induced found very complex among addition, it confirmed that using determine geographic environments yield results.